Current Issue : October-December Volume : 2023 Issue Number : 4 Articles : 1 Articles
Diabetes mellitus, a worldwide health concern, is associated with a plethora of complications, among which impaired wound healing in diabetic individuals stands as a significant challenge. This study explores the potential of natural products in diabetic wound healing, with a particular focus on embelin, a natural compound found in Embelia ribes Burm. Embelin has been identified in previous research for its diverse biological properties, including wound-healing capabilities. However, the precise molecular mechanisms underlying embelin's effects on diabetic wound healing remain unclear. This study employs network pharmacology to unravel the intricate relationships between embelin and diabetic wound healing, providing insights into its potential therapeutic benefits. The investigation identifies key proteins such as IL6, EGFR, PPARG, MMP9 and ERBB2 as central players in the network of embelin's action. KEGG pathway analysis further underscores the importance of embelin in managing diabetic wounds by modulating critical pathways associated with cancer, TNF signalling, virus infections and tissue repair. This holistic approach recognizes the potential of natural remedies, specifically embelin, in addressing the complexities of diabetic wound care and offers a promising avenue for further research and therapeutic development....
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